Try deleting a cell, moving down and deleting another. Do this whilst recording the macro and you have the bare bones of your code.
Place this in a for next loop but I would suggest going from i= 353 to 1 step -1
Use RC references i.e. activesheet.cells(2,4) and you can replace the 2 or the 4 with i or j for doing the five columns.
You are testing to see if activesheet.cells(2,4).value = ""